Hosts and Consequences of Human CoV Infection

Ankita Singh

Published Date: 2020-08-10
DOI10.36648/2576-3903.5.2.4
Ankita Singh*

Department of Biotechnology, Modern College of Arts, Science and Commerce, Ganeshkhind, Pune, India

*Corresponding Author:
Ankita Singh
Department of Biotechnology, Modern College of Arts, Science and Commerce, Ganeshkhind, Pune, India
E-mail: ankitabiotechnologist@gmail.com

Received: August 03, 2020; Accepted: August 10, 2020; Published: August 17, 2020

Citation: Singh A (2020) Hosts and Consequences of Human CoV Infection. J Neoplasm Vol.5 No.2:4. doi: 10.36648/2576-3903.5.2.4

Visit for more related articles at Journal of Neoplasm

Abstract

Various human Coronaviruses such as Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have a different natural host like a bat, mouse and intermediate hosts like a cow, camel, Maylitan Pangolin while human host such as HCoV-NL63, HCoV-OC43, HCoV-229E, HCoV-HKU1 cause mild infection in the human body whereas SARS-CoV-2, MERS-CoV, and SARS-CoV cause mild or severe human disease like respiratory, cardiovascular, digestive disease depending upon the host condition and strain type of viruses. There are various viral receptors such as Angiotensin I-Converting Enzyme 2 (ACE2), ANPEP (also known as CD13), 9-O-acetylated sialic acids (9-0-Ac-Sia); DPP4 (also known as CD26), dipeptidyl peptidase 4 which helps in the invasion. Upon the invasion of SARS-CoV-2, there are structural changes in the host cells found in the human airway epithelial cells (at 96 hours).

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