Department of Biotechnology, Modern College of Arts, Science and Commerce, Ganeshkhind, Pune, India
Department of Biotechnology,
Modern College of Arts, Science and
Commerce, Ganeshkhind, Pune, India
E-mail: [email protected]
Received: August 01, 2020; Accepted: August 07, 2020; Published: August 17, 2020
Citation: Singh A (2020) SARS-CoV-2-Proposed Mechanism. J Neoplasm Vol.5 No.2:3 doi: 10.36648/2576-3903.5.2.3
Possible mechanism of action of SARS-COV-2. For the binding of SARS-COV-2 to its ACE-2 (Angiotensin-converting enzyme) receptor present in the respiratory epithelium and alveoli of the lungs, the subunits of S protein cleaved into S1 and S2 domains by the proteases followed by cleaving and shedding of ACE-2 by ADAM 17 into the extra membrane space, which leads to a reduction in the amount of Angiotensin ll causes vascular permeability and alveoli injury by conversion of angiotensin I to angiotensin II by ACE2 leads to respiratory distress.