Journal of Neoplasm

Impact of Radiation Dose inSubventricular Zone on Survival in Glioblastoma Multiforme: A Mini Review

GlioblastomaMultiforme (WHO GRADE IV) constitutes 75% of all high grade glial cell tumors in the central nervous system.The general management consists of maximal tumor resection followed by adjuvant radiation and chemotherapy. Thereexists a controversial role of neural stem cells residing in subventricular zone and the location of tumor with respect to it and the probability of the recurrence with respect to it. An intense review on literature and studies were found which showed varied results on the pattern of recurrence and the overall survival and time to progression by the irradiation of subventricular zone in patients of Glioblastoma Multiforme to high doses. All these studies incorporated 3 dimensional conformal radiotherapy or Intensity Modulated Radiotherapy as preferred modality for radiation planning modality. They showed that initial contact of primary tumor to Subventricular zone was associated with a high probability of recurrence but prophylactic irradiation of bilateral Subventricular zone to high doses is still questionable keeping in mind its close proximity to hippocampus where studies are going on hippocampal sparing radiation techniques. All of these have not arrived at a common conclusion.GlioblastomaMultiforme tumors involving Subventricular zone can be an independent poor prognostic factor,but prophylactic irradiation of bilateral subventricularzone to high doses is still questionable.

Author(s):

Aastha Shah^*,RajanYadav, Isha Shah and Monik Patel

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