Journal of Neoplasm

Reduced Intensity Unmanipulated Haploidentical Stem Cell Transplantation for Relapsed High risk Neuroblastoma after Autologous Stem Cell Transplantation

Background

Neuroblastoma (NB) is one of the most common indications for autologous Stem Cell Transplantation (SCT) in pediatrics, however, the main cause of treatment failure after autologous SCT is relapse/progression. This unsatisfactory results, together with the growing insights in the mechanisms of graft-versus-tumor effects has inspired trials investigating allogenic SCT. 

Case Reports

The first patient was a 20-year-old male with progression of high risk NB, 4 years after High Dose Chemotherapy with Autologous Peripheral Blood Stem Cell Rescue (HDCT/ASCT), referred with multiple 123-Metaiodobenzyl Guanidine (MIBG) avid metastatic lesions. He underwent salvage chemotherapy and MIBG-therapy, after which imaging revealed no MIBG-avid tumoral lesion throught the body. He received peripheral blood stem cell transplant from his HLA-haploidentical father and has remained disease free for more than 3 years, until the prestent time. 

The second patient was a 14-year-old boy with high risk NB who presneted with multiple MIBG-avid tumoral masses 5 years after HDCT/ASCT. After salvage chemotherapy and MIBG-therapy, imaging demonstrated MIBG-avid tumoral lesion in the left 12th rib. He received peripheral blood stem cell transplant from his HLA-haploidentical father. The lesion remained stable on the MIBG scan, until +270 days post transplant, however, it showed progression in the CT scan conducted on +365 days post SCT.

 

 

Author(s):

Tahereh Rostami, Amirabas Hedayati Asl, Reyhaneh Manafi-Farid, Azadeh Kiumarsi^* and Seied Asadollah Mousavi

Abstract | PDF

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