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Abstract

SARS-CoV-2-Proposed Mechanism

Possible mechanism of action of SARS-COV-2. For the binding of SARS-COV-2 to its ACE-2 (Angiotensin-converting enzyme) receptor present in the respiratory epithelium and alveoli of the lungs, the subunits of S protein cleaved into S1 and S2 domains by the proteases followed by cleaving and shedding of ACE-2 by ADAM 17 into the extra membrane space, which leads to a reduction in the amount of Angiotensin ll causes vascular permeability and alveoli injury by conversion of angiotensin I to angiotensin II by ACE2 leads to respiratory distress.


Author(s):

Ankita Singh



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