Journal of Neoplasm

Connections between Warburg’s and Szentgyorgyi’s Approach about the Causes of Cancer

Numerous theories and hypotheses are published about the causes of cancer and its hallmarks. Two remarkable principles were established and debated for a long time. The first is the Warburg-effect, which based on mitochondrial dysfunction, connected to the intensive metabolic activity of the malignancy. The other is the Szentgyorgyi’s effect which describes the malignancy by changing of the cellular state (α ↔ β) explained by evolutional biology and supported by definitely improved dielectric properties of the malignant tissue from their normal counterpart while these theories have stable explanations, developed many controversies. Both are partial of completely revised time-by-time, showing new insights with new evidence as additions to these old ideas. Our objective is to demonstrate connections between these theories and start new considerations in the actual debates.

Author(s):

Szigeti GP, Szasz O and Hegyi G

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