Journal of Neoplasm

The Role of BRCA1 and BRCA2 Genes in the Appearance of Pediatric and Adolescent Disorders

The genes BRCA1 and BRCA2 appear crucial role in development of hereditary breast and ovarian cancer. Hundreds of different types of mutations have been identified in these genes. The high risk mutations inactivate a very important and foolproof DNA repair process, thus increasing considerably the risk of diseases development such as breast and ovarian cancer.

These genes seem to have a significant influence and participation in appearance of pediatric diseases other than breast and ovarian cancer being important molecules in DNA repair process and cell cycle progression. Therefore further exploration and evaluation of these genes in the appearance of pediatric diseases may enhance the importance of prenatal audit.

Author(s):

Ioannis Drikos, Alexandros Sachinidis, Ioanna Vassi4, Effrossyni Boutou

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